Peking and the Mysterious West

The task of keeping the Western world, or at least the United States, convinced that Chairman Mao and his current associates in the Forbidden City at Peking are madmen is both demanding and deadening. The Russian Communist leaders in Moscow, it is estimated, devote six days weekly to the chore, a stint paralleled by the Chinese Nationalist leaders in Taipei. Dedicated anti-Communists from New York to Long Beach contribute significantly to the effort, And the Chinese Communists themselves, not to be outdone, appear to allot roughly half their working hours to programs designed to convince the American Congress that they are not only intransigent but also intellectually insolvent and emotionally unbalanced. Given the din, it is hardly surprising that the intelligent layman surrenders both diagnosis and prognosis to the China experts

New salt marshes for old: salt marsh creation and management

Abstract Salt marshes are vulnerable to rising sea levels, coastal developments, pollution and disturbance, and at the same time they provide economic, social and environmental benefits. Recently salt marsh re-creation has been undertaken in the interest of both sea defence and nature conservation. The vegetation pattern on these newly created marshes is very different from that found on mature marshes. This suggests that the soil conditions may be limiting normal vegetation development and implies that special techniques will be needed to enhance the processes involved. For pioneer salt marsh to develop a proportion of the sediment load in the water covering the marsh at high tide has to be trapped by salt marsh plants and subsequently incorporated into the marsh substrate. This paper presents the results of recent experimental studies in this area of research and examines various aspects of the key processes involved and the critical implications for salt marsh management and coastal defence

A Top-Down Approach for a Synthetic Autobiographical Memory System

Autobiographical memory (AM) refers to the organisation of one’s experience into a coherent narrative. The exact neural mechanisms responsible for the manifestation of AM in humans are unknown. On the other hand, the field of psychology has provided us with useful understanding about the functionality of a bio-inspired synthetic AM (SAM) system, in a higher level of description. This paper is concerned with a top-down approach to SAM, where known components and organisation guide the architecture but the unknown details of each module are abstracted. By using Bayesian latent variable models we obtain a transparent SAM system with which we can interact in a structured way. This allows us to reveal the properties of specific sub-modules and map them to functionality observed in biological systems. The top-down approach can cope well with the high performance requirements of a bio-inspired cognitive system. This is demonstrated in experiments using faces data

Coupling between gamma-band power and cerebral blood volume during recurrent acute neocortical seizures

Characterization of neural and hemodynamic biomarkers of epileptic activity that can be measured using non-invasive techniques is fundamental to the accurate identification of the epileptogenic zone (EZ) in the clinical setting. Recently, oscillations at gamma-band frequencies and above (>30 Hz) have been suggested to provide valuable localizing information of the EZ and track cortical activation associated with epileptogenic processes. Although a tight coupling between gamma-band activity and hemodynamic-based signals has been consistently demonstrated in non-pathological conditions, very little is known about whether such a relationship is maintained in epilepsy and the laminar etiology of these signals. Confirmation of this relationship may elucidate the underpinnings of perfusion-based signals in epilepsy and the potential value of localizing the EZ using hemodynamic correlates of pathological rhythms. Here, we use concurrent multi-depth electrophysiology and 2-dimensional optical imaging spectroscopy to examine the coupling between multi-band neural activity and cerebral blood volume (CBV) during recurrent acute focal neocortical seizures in the urethane-anesthetized rat. We show a powerful correlation between gamma-band power (25-90 Hz) and CBV across cortical laminae, in particular layer 5, and a close association between gamma measures and multi-unit activity (MUA). Our findings provide insights into the laminar electrophysiological basis of perfusion-based imaging signals in the epileptic state and may have implications for further research using non-invasive multi-modal techniques to localize epileptogenic tissue

Higher education, mature students and employment goals: policies and practices in the UK

This article considers recent policies of Higher Education in the UK, which are aimed at widening participation and meeting the needs of employers. The focus is on the growing population of part-time students, and the implications of policies for this group. The article takes a critical perspective on government policies, using data from a major study of mature part-time students, conducted in two specialist institutions in the UK, a London University college and a distance learning university. Findings from this study throw doubt on the feasibility of determining a priori what kind of study pathway is most conducive for the individual in terms of employment gains and opportunities for upward social mobility. In conclusion, doubts are raised as to whether policies such as those of the present UK government are likely to achieve its aims. Such policies are not unique to the UK, and lessons from this country are relevant to most of the developed world

Comparison of stimulus-evoked cerebral hemodynamics in the awake mouse and under a novel anesthetic regime

Neural activity is closely followed by a localised change in cerebral blood flow, a process termed neurovascular coupling. These hemodynamic changes form the basis of contrast in functional magnetic resonance imaging (fMRI) and are used as a correlate for neural activity. Anesthesia is widely employed in animal fMRI and neurovascular studies, however anesthetics are known to profoundly affect neural and vascular physiology, particularly in mice. Therefore, we investigated the efficacy of a novel ‘modular’ anesthesia that combined injectable (fentanyl-fluanisone/midazolam) and volatile (isoflurane) anesthetics in mice. To characterize sensory-evoked cortical hemodynamic responses, we used optical imaging spectroscopy to produce functional maps of changes in tissue oxygenation and blood volume in response to mechanical whisker stimulation. Following fine-tuning of the anesthetic regime, stimulation elicited large and robust hemodynamic responses in the somatosensory cortex, characterized by fast arterial activation, increases in total and oxygenated hemoglobin, and decreases in deoxygenated hemoglobin. Overall, the magnitude and speed of evoked hemodynamic responses under anesthesia resembled those in the awake state, indicating that the novel anesthetic combination significantly minimizes the impact of anesthesia. Our findings have broad implications for both neurovascular research and longitudinal fMRI studies that increasingly require the use of genetically engineered mice